The conference “Integrated and innovative key actions for mycotoxin management in the food and feed chain” was jointly organized by International Society of Mycotoxicology, Mycokey, and MycoTWIN projects in Bari, Italy on 9-12 November 2021.The meeting started with an overview of the main scientific achievements of the MycoKey project and was therefore focused on the updates on Toxigenic fungi and related mycotoxins by presentations of International Keynote Speakers. Moreover, MycoTWIN project was presented and related Workshops based on selected topics was carried out on the behalf of the meeting. Finally, the conference hosted also the 2nd International Forum on Mycotoxins in Animal Production. Due to the COVID emergency, this international Conference was organized as a hybrid Conference, since both in situ and online presentations were allowed.